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History of Local Anesthetic Systemic Toxicity

September 4, 2009 | Leave a Comment

Local anesthetic toxicity was recognized even before cocaine was introduced as a surgical anesthetic in humans. In 1868, the first report of cocaine-induced seizures in animals was cited by Moreno y Maiz. At the same time, Maiz also reported cutaneous anesthesia and asked whether cocaine might be used as a local anesthetic. Almost 20 years [...]

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